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NAME: Paul Richard Adams DATE: Feb 2006


PRESENT POSITION & ADDRESS: Professor, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook New York 11794


1968 B.A. Physiology and Pharmacology Cambridge University, England

1974 Ph.D. Pharmacology London University, England




1984 -Present Professor, Department of Neurobiology & Behavior, SUNY at Stony Brook.

1987-1995 Investigator, Howard Hughes Medical Institute, SUNY at Stony Brook

1981-1984 Associate Professor, Department of Neurobiology & Behavior, SUNY at Stony Brook.

1980-1981 Associate Professor, Department of Physiology & Biophysics, University of Texas Medical Branch, Galveston, Texas

1977-1980 Assistant Professor, Department of Physiology & Biophysics, University of Texas, Medical Branch, Galveston, Texas

1976-1977Chargé de recherche, CNRS, Laboratoire de Neurobiologie, Ecole Normale Supérieure Paris, France

1975-1976 Stipendiate of Max Planck Gesellschaft, M.P.I. für Biophys. Chemie, Göttingen, West Germany

1971-1974 Lecturer, Department of Pharmacology, Bart's Medical College, London, England

1968-1971 MRC Scholar, Bart's Hospital Medical School, London, England


Fellow of the Royal Society (1991)

Howard Hughes Medical Institute Investigator (1987-1995)

MacArthur Foundation Prize Fellow (1986-1991)

Gaddum Memorial Lecturer, British Pharmacological Society (1984)

Klingenstein Fund Senior Fellow (1981-1984)

Sloan Fellow (1979-1980)

Sandoz Prize of British Pharmacological Society (1979)


Selected Publications


Pringle, M.J. & Adams, P.R. 1975. Modification by procaine of membrane ANS fluorescence changes induced by electrical stimulation of nerve and muscle fibres. Biochem. Biophys. Res. Comm. 65:196-204.

Adams, P.R. 1975. Kinetics of agonist conductance changes during hyperpolarization at frog endplates. Br. J. Pharmacol. 53:308-310.

Adams, P.R. & Brown, D.A. 1975. Actions of g-aminobutyric acid on sympathetic ganglion cells. J. Physiol. 250:85-120.

Adams, P.R. 1975. A study of desensitization using voltage clamp. Pflügers Archiv. 360:l35-l44.

Adams, P.R. 1975. An analysis of the dose-response curve at voltage-clamped frog endplates. Pflügers Archiv. 360:145-153.

Adams, P.R. 1976. Drug blockade of open end-plate channels. J. Physiol. 260:531-552.

Adams, P.R. 1977. Voltage jump analysis of procaine action at frog endplate. J. Physiol. 268:291-318.

Adams, P.R. & Sakmann, B. 1978. Decamethonium both opens and blocks endplate channels. Proc. Nat. Acad. Sci. 75:2994-2998.

Adams, P.R. 1978. Molecular aspects of synaptic transmission. Trends Neurosci. 1:141-144

Brown, D.A. & Adams, P.R. l980. Muscarinic suppression of a novel voltage-sensitive K+-current in a vertebrate neurone. Nature 283:673-676.

Adams, P.R. & Brown, D.A. 1980. Luteinizing hormone-releasing factor and muscarinic agonists act on the same voltage-sensitive K+ -currents in bullfrog sympathetic neurones. Br. J. Pharmac. 68:353-355.

Adams, P.R. 1982. Voltage-dependent conductances of vertebrate neurones. Trends in Neurosci. 5:116-119.

Adams, P.R., Constanti, A., Brown, D.A. & Clark, R.B. 1982. Intracellular Ca2+ activates a fast voltage-sensitive K+-current in vertebrate sympathetic neurones. Nature 296:746-749.


Halliwell, J.V. & Adams, P.R. 1982. Voltage clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250:71-92.


Adams, P.R. & Brown, D.A. 1982. Synaptic inhibition of the M-current: Mechanism of the slow excitatory potential in bullfrog sympathetic neurones. J. Physiol. 332:263-272


Adams, P.R., Brown, D.A. & Constanti, A. 1982. M-currents and other K+-currents in bullfrog sympathetic neurones. J. Phyiol. 330:537-572.

Pennefather, P., Lancaster, B., Adams, P.R. & Nicoll, R.A. 1985. Two distinct Ca-activated K-currents in bullfrog ganglion cells. Proc. Natl. Acad. Sci. 82:3040-3044.

Lancaster, B. & Adams, P.R. 1986. Calcium-dependent current generating the after-hyperpolarization of hippocampal neurons. J. Neurophysiol. 55:1268-1282.

Scharfman, H.E., Lu, S.M., Guido, W., Adams, P.R. & Sherman, S.M. 1990. N-Methyl-D-Aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proceedings of the National Academy of Science, 87:4548-4552.

Hernandez-Cruz, A., Sala, F. & Adams, P.R. 1990. Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron. Science, 247:858-862.

Zhou,Q., Godwin, D.W., O'Malley. D.M. & Adams, P.R. (1997). Visualisation of calcium influx through channels that shape the burst and tonic firing modes of thalamic relay cells. J. Neurophysiol. 77: 2816 - 2825.

Adams,P.R. (1998) Hebb and Darwin. J. Theoretic. Biol. 195:419-438

Cox,K.J.A. & Adams,P.R. (2000) Implications of synaptic digitisation and error for neocortical function Neurocomputing 32 673-678

Adams,P.R. 2000. To sleep perchance to dream: the neocortical basis of mind, sleep and dreams. Science Spectra 23, 46-55.

Adams, P.R. & Cox, K.J.A. (2001) Synaptic Darwinism and neocortical function. Neurocomputing. 42, 197-214

Adams,P. & Cox, K. (2002) A New View of Thalamocortical Function. Phil Trans R. Soc Lond B 357, 1767-1779


Chapters in Books:

Sakmann, B. & Adams, P.R. 1978. Biophysical aspects of agonist action at frog endplate. In: "Advances in Pharmacology and Therapeutics, Vol. l, Receptors." Editor: J. Jacob, 81-90. Pergamon Press.

Adams, P.R. 1987. Cholinergic hypothesis of Alzheimer's disease: biophysical aspects. In: "Molecular Neurobiology in Neurology and Psychiatry". Editor: E.R. Kandel, 169-185. Raven Press, NY.