PRESENT POSITION & ADDRESS: Professor, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook New York 11794

EDUCATION:

1968 B.A. Physiology and Pharmacology Cambridge University, England

1974 Ph.D. Pharmacology London University, England

PROFESSIONAL & TEACHING EXPERIENCE:

1984 -Present Professor, Department of Neurobiology & Behavior, SUNY at Stony Brook.

1987-1995 Investigator, Howard Hughes Medical Institute, SUNY at Stony Brook

1981-1984 Associate Professor, Department of Neurobiology & Behavior, SUNY at Stony Brook.

1980-1981 Associate Professor, Department of Physiology & Biophysics, University of Texas Medical Branch, Galveston, Texas

1977-1980 Assistant Professor, Department of Physiology & Biophysics, University of Texas, Medical Branch, Galveston, Texas

1976-1977Chargé de recherche, CNRS, Laboratoire de Neurobiologie, Ecole Normale Supérieure Paris, France

1975-1976 Stipendiate of Max Planck Gesellschaft, M.P.I. für Biophys. Chemie, Göttingen, West Germany

1971-1974 Lecturer, Department of Pharmacology, Bart's Medical College, London, England

1968-1971 MRC Scholar, Bart's Hospital Medical School, London, England

HONORS:

Fellow of the Royal Society (1991)

Howard Hughes Medical Institute Investigator (1987-1995)

MacArthur Foundation Prize Fellow (1986-1991)

Gaddum Memorial Lecturer, British Pharmacological Society (1984)

Klingenstein Fund Senior Fellow (1981-1984)

Sloan Fellow (1979-1980)

Sandoz Prize of British Pharmacological Society (1979)

Selected Publications

Articles:

Pringle, M.J. & Adams, P.R. 1975. Modification by procaine of membrane ANS fluorescence changes induced by electrical stimulation of nerve and muscle fibres. Biochem. Biophys. Res. Comm. 65:196-204.

Adams, P.R. 1975. Kinetics of agonist conductance changes during hyperpolarization at frog endplates. Br. J. Pharmacol. 53:308-310.

Adams, P.R. 1975. A study of desensitization using voltage clamp. Pflügers Archiv. 360:l35-l44.

Adams, P.R. 1975. An analysis of the dose-response curve at voltage-clamped frog endplates. Pflügers Archiv. 360:145-153.

Adams, P.R. 1976. Drug blockade of open end-plate channels. J. Physiol. 260:531-552.

Adams, P.R. 1977. Voltage jump analysis of procaine action at frog endplate. J. Physiol. 268:291-318.

Adams, P.R. & Sakmann, B. 1978. Decamethonium both opens and blocks endplate channels. Proc. Nat. Acad. Sci. 75:2994-2998.

Adams, P.R. 1978. Molecular aspects of synaptic transmission. Trends Neurosci. 1:141-144

Brown, D.A. & Adams, P.R. l980. Muscarinic suppression of a novel voltage-sensitive K⁺-current in a vertebrate neurone. Nature 283:673-676.

Adams, P.R. & Brown, D.A. 1980. Luteinizing hormone-releasing factor and muscarinic agonists act on the same voltage-sensitive K⁺ -currents in bullfrog sympathetic neurones. Br. J. Pharmac. 68:353-355.

Adams, P.R. 1982. Voltage-dependent conductances of vertebrate neurones. Trends in Neurosci. 5:116-119.

Adams, P.R., Constanti, A., Brown, D.A. & Clark, R.B. 1982. Intracellular Ca²⁺ activates a fast voltage-sensitive K⁺-current in vertebrate sympathetic neurones. Nature 296:746-749.

Halliwell, J.V. & Adams, P.R. 1982. Voltage clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250:71-92.

Adams, P.R. & Brown, D.A. 1982. Synaptic inhibition of the M-current: Mechanism of the slow excitatory potential in bullfrog sympathetic neurones. J. Physiol. 332:263-272

Adams, P.R., Brown, D.A. & Constanti, A. 1982. M-currents and other K⁺-currents in bullfrog sympathetic neurones. J. Phyiol. 330:537-572.

Pennefather, P., Lancaster, B., Adams, P.R. & Nicoll, R.A. 1985. Two distinct Ca-activated K-currents in bullfrog ganglion cells. Proc. Natl. Acad. Sci. 82:3040-3044.

Lancaster, B. & Adams, P.R. 1986. Calcium-dependent current generating the after-hyperpolarization of hippocampal neurons. J. Neurophysiol. 55:1268-1282.

Scharfman, H.E., Lu, S.M., Guido, W., Adams, P.R. & Sherman, S.M. 1990. N-Methyl-D-Aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proceedings of the National Academy of Science, 87:4548-4552.

Hernandez-Cruz, A., Sala, F. & Adams, P.R. 1990. Subcellular calcium transients visualized by confocal microscopy in a voltage-clamped vertebrate neuron. Science, 247:858-862.

Zhou,Q., Godwin, D.W., O'Malley. D.M. & Adams, P.R. (1997). Visualisation of calcium influx through channels that shape the burst and tonic firing modes of thalamic relay cells. J. Neurophysiol. 77: 2816 - 2825.

Adams,P.R. (1998) Hebb and Darwin. J. Theoretic. Biol. 195:419-438

Cox,K.J.A. & Adams,P.R. (2000) Implications of synaptic digitisation and error for neocortical function Neurocomputing 32 673-678

Adams,P.R. 2000. To sleep perchance to dream: the neocortical basis of mind, sleep and dreams. Science Spectra 23, 46-55.

Adams, P.R. & Cox, K.J.A. (2001) Synaptic Darwinism and neocortical function. Neurocomputing. 42, 197-214

Adams,P. & Cox, K. (2002) A New View of Thalamocortical Function. Phil Trans R. Soc Lond B 357, 1767-1779

Sakmann, B. & Adams, P.R. 1978. Biophysical aspects of agonist action at frog endplate. In: "Advances in Pharmacology and Therapeutics, Vol. l, Receptors." Editor: J. Jacob, 81-90. Pergamon Press.

Adams, P.R. 1987. Cholinergic hypothesis of Alzheimer's disease: biophysical aspects. In: "Molecular Neurobiology in Neurology and Psychiatry". Editor: E.R. Kandel, 169-185. Raven Press, NY.